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Report of Three Cases with Description of Treatment and Recovery

DOUGLAS GOLDMAN, M.D.

AMA Arch Intern Med. 1955;96(4):496-499.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

For more than 20 years, it has been recog nized that aromatic organic compounds containing nitrogen atoms in certain linkages are capable of producing serious depression of leucocyte production and agranulocytosis; therefore, it is not surprising that after a period of extensive use of chlorpromazine, which is such an organic compound (Figure), this complication from the use of the drug should be encountered.

It is not considered necessary to discuss the history of the recognition of agranulocytosis as a specific entity or the development of certain aspects of the treatment, which are covered adequately in the systems of medicine. Particular reference is made to the chapter on agranulocytosis in the Oxford Medicine, by Dameshek.

The patients who form the basis of this report were a part of the series of psychotic patients in treatment at Longview State Hospital, Cincinnati. The chlorpromazine was given for treatment of various psychotic states. At . . . [Full Text PDF of this Article]

Author Affiliations
Cincinnati

From Longview State Hospital; Dr. E. A. Baber, Superintendent.

Footnotes
Submitted for publication April 6, 1955.

Chlorpromazine was furnished, as Thorazine, through the courtesy of Smith, Kline & French Laboratories.

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