This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (9)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

LT. CMDR. CARROLL M. LEEVY, MC; ANGELO M. GNASSI, M.D.; MARTIN W. POLLINI, M.D.

AMA Arch Intern Med. 1955;96(4):507-517.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The pathogenesis,* biological effects, and reversibility of hepatic fibrosis have been extensively studied in experimental animals. Difference in structure and physiology of the liver in humans and in lower vertebrates prevents direct application of these findings to man.¹² Postmortem observations and in vivo biopsies || correlated with animal experiments provide a background for additional study. This paper records further clinical observations on the histogenesis, significance, and influence of therapy on hepatic fibrosis. The study is based on serial needle biopsies of the liver correlated with clinical and biochemical abnormalities.

MATERIALS AND METHODS

Clinical material included 237 patients with nutritional liver disease, 41 with extrahepatic biliary obstruction, 30 with viral hepatitis, and 75 with congestive heart failure. Liver-function tests used in these patients included determination of serum bilirubin,²⁶ serum alkaline phosphatase,²⁷ sulfobromophthalein excretion,²⁸ serum cholesterol and esters,²⁹ serum albumin and globulin,³⁰ cephalin flocculation,³¹ . . . [Full Text PDF of this Article]

Author Affiliations
U. S. N. R. St. Albans, Long Island, N. Y.; Jersey City, N. J.

From the Departments of Medicine and Pathology, Jersey City Medical Center.

Footnotes
Submitted for publication July 13, 19SS.

Read before the Joint Meeting of the Section on Gastroenterology and Proctology and the Section on Pathology and Physiology at the 104th Annual Meeting of the American Medical Association, Atlantic City, June 9, 1955.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?