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Absence of Diffuse Lesions at Autopsy and in Biopsies

B. H. KEAN, M.D.

AMA Arch Intern Med. 1955;96(5):667-673.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The clinical syndrome of amebic hepatitis consists of hepatomegaly, hepatic tenderness, slight to moderate fever, moderate leucocytosis, and laboratory evidence of hepatic dysfunction in a patient with a history of intestinal amebiasis.* An important feature is response to specific antiamebic therapy. The lesion in the liver is assumed to be a diffuse hepatitis caused by Endamoeba histolytica in contrast to the classic localized amebic abscess.

The purpose of this paper is to report the absence of specific diffuse hepatic lesions in (I) a large series of autopsies from an area where the incidence of intestinal amebiasis is moderately high; (II) 148 persons who died of amebiasis; (III) 50 patients with the clinical pattern of diffuse amebic hepatitis who were subjected to liver biopsy.

DEFINITIONS

The following definitions will be employed to distinguish terms which have been used synonymously and which may represent different entities.

Amebic Abscess of Liver: A localized . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Department of Medicine and the Central Laboratories, The New York Hospital-Cornell Medical Center.

Footnotes
Submitted for publication June 17, 1955.

The following members of the staff of the Armed Forces Institutes of Pathology, Washington, D.C., aided in this study: Brig. Gen. Elbert De Coursey (MC), A. U. S., The Director, gave permission to utilize the pathological material and facilities; Col. Hugh R. Gilmore Jr. (MC), A.U.S., Curator, Medical Museum, actively participated in several phases of the study; Dr. Hans Smetana gave advice; Dr. I. N. Dubin provided the cases which were studied by the biopsy technique, and Major Gen. M. C. Stayer (MC), A.U.S., formerly Chief Health Officer, The Panama Canal, and Dr. Lewis Beals Bates, formerly Chief, Board of Health Laboratory, Gorgas Hospital, cooperated in the Canal Zone phase of the project.

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