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Control of Nausea and VomitingIncidence of Side-Effects
C. R. STEPHEN, M.D.;
S. DENT, M.D.;
M. BOURGEOIS-GAVARDIN, M.D.
AMA Arch Intern Med. 1955;96(6):794-798.
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Nausea and vomiting are distressing symptoms which denote irritation or abnormal stimulation of the vomiting center, which lies in the medulla oblongata. Etiological factors are diverse and may influence the emesis center directly or, perhaps more frequently, the chemoreceptor trigger zone, which lies more superficially in the medulla.1
Of the many drugs which have been advocated to prevent or control emesis, none has achieved such a universal acceptance in a short period as chlorpromazine. It has given clinical protection in apomorphineinduced vomiting,2 in uremia,3 in irradiation sickness,4 in postoperative vomiting,5 and in several miscellaneous conditions, including the vomiting of pregnancy.6 Experimental evidence suggests that chlorpromazine exerts an action directly on the chemoreceptive trigger zone.7 The only dissenting voice against the reliability of chlorpromazine in controlling nausea and vomiting has come from an experienced group who state it gave no significant protection in motion sickness.8
Before such a drug as chlorpromazine
. . . [Full Text PDF of this Article]
Author Affiliations
Durham, N. C.
From the Division of Anesthesiology, Duke Hospital and University School of Medicine.
Footnotes
Submitted for publication July 13, 1955.
Read before the Section on Gastroenterology and Proctology at the 104th Annual Meeting of the American Medical Association, Atlantic City, June 8, 1955.
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