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Pfeifer-Weber-Christian Disease; Report of Three Cases

NINA POPOFF, M.D.; M. C. WHEELOCK, M.D.

AMA Arch Intern Med. 1956;97(1):39-44.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Relapsing febrile nodular nonsuppurative panniculitis is a syndrome of unknown etiology. It is characterized by a recurrent, nodular, nonsuppurative, inflammatory process in the subcutaneous fat. The outbreak of lesions is usually, but by no means necessarily, accompanied by a low-grade fever. The nodules occur most often on the legs, thighs, abdomen, and breasts. They vary from a few millimeters to several centimeters in diameter. Rarely, similar manifestations have been noticed in epicardial, peripancreatic, perirenal, periadrenal, and mesenteric adipose tissues. A fatal case of this type was reported by Mostofi and Engleman.¹¹ The disease usually affects women, the ratio of the incidence being 3:1. The condition manifests itself most frequently between the second and fourth decades. Three cases in Negroes have been reported in the literature.

No specific therapy is known. Antibiotics and sulfonamides, especially sulfapyridine, have been used in some instances. Cortisone and corticotropin (ACTH) do not provide a . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

From the Department of Pathology, Passavant Memorial Hospital and Northwestern University Medical School.

Footnotes
Submitted for publication July 29, 1955.

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