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Studies on Adrenocortical and Psychological Response to Stress in man
S. RICHARDSON HILL, Jr., M.D.;
FREDERICK C. GOETZ, M.D.;
HENRY M. FOX, M.D.;
BENJAMIN J. MURAWSKI, Ph.D.;
LEWIS J. KRAKAUER, M.D.;
ROBERT W. REIFENSTEIN, M.D.;
SEYMOUR J. GRAY, M.D.;
WILLIAM J. REDDY, A.B.;
STEPHEN E. HEDBERG, M.D.;
JACQUES R. ST. MARC, M.D.;
GEORGE W. THORN, M.D.
AMA Arch Intern Med. 1956;97(3):269-298.
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Introduction
- Methods
- Metabolic
- Statistical
- Psychologic
- Metabolic Observations
- Eosinophile level
- Urinary total 17-hydroxycorticoid excretion
- Urinary 17-ketosteroid excretion
- Uropepsin excretion
- Correlations between 17-hydroxycorticoids, 17-ketosteroids, and uropepsin values
- Complementary studies
- Long-distance running
- Studies on 17-hydroxycorticoid excretion in sweat
- "Utilization" studies
- Metabolic Interpretations
- Adrenocortical secretory response to the race "Increased utilization"
- Eosinophile levels and 17-hydroxycorticoid excretion
- Physical exercise vs. psychological stress
- Psychological Observations
- Group Rorschach
- Thematic Apperception Test
- Personal interviews
- Psychological Interpretation
- Summary of psychological findings on the crew
- Supplementary studies of psychologic stress and adrenal cortical activation
- Metabolic and Psychological Correlation
- Conclusions
- References
INTRODUCTION
Evaluation of the role of the adrenal cortex in the response of man to stressful situations continues to be a problem of major interest to medical investigators. Earlier studies suggested that the adrenal cortex responds actively and promptly to many, but not all, psychic and physical stresses.1 In many of the studies, changes in the level of circulating
. . . [Full Text PDF of this Article]
Author Affiliations
Boston
From the Departments of Medicine and Psychiatry, Harvard Medical School, and the Department of Medicine, Peter Bent Brigham Hospital; present address: Medical College of Alabama and Veterans Administration Hospital, Birmingham, Ala. (Dr. Hill).
Footnotes
Submitted for publication Sept. 2, 1955.
Dr. Thomas B. Quigley, Dr. Harrison E. Kennard, Mr. Harvey M. Love, and Mr. Joseph Murphy cooperated in arranging for and assisting with these studies. Dr. William E. Reynolds and Dr. Mindel C. Sheps gave advice and assistance in regard to statistical analysis of the data. The members and managers of the varsity crews cooperated in this study.
These studies were supported by funds from the National Institutes of Health of the United States Public Health Service; the Eugene Higgins Trust of the Harvard Medical School, the Ford Foundation, and the Medical Research and Development Board, Office of the Surgeon General, Department of the Army, under Contract Nos. DA-49-007-MD-135 and DA-49-007-MD-213.
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