This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (79)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

DAVID C. H. SUN, M.D., D.Sc. (Med.); HARRY SHAY, M.D.

AMA Arch Intern Med. 1956;97(4):442-452.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In our previous study ¹ on the effect of different doses of an anticholinergic drug in the same patient, we found that suppression of gastric acidity to pH 4.5 or higher did not occur at any dose without accompanying dryness of the mouth but that the dose producing dryness of the mouth did not necessarily bring about such pH values of acidity. However, if the dose of these drugs was increased to one increment below that which produced uncomfortable symptoms of parasympathetic inhibition, such as blurring of vision, palpitation, dizziness, headache, weakness, flushing of the face, and/or excessive dryness of the mouth and throat, suppression of acidity to pH 4.5 or higher occurred consistently with the effective drugs. This dose we termed the optimal effective dose (O. E. D.).

The present study was undertaken to investigate the value of the optimal effective dose of anticholinergic drugs and to appraise its . . . [Full Text PDF of this Article]

Author Affiliations
Philadelphia

From the Samuel S. Fels Research Institute, Temple University School of Medicine.

Footnotes
Submitted for publication Aug. 19, 1955.

Read before the Section on Gastroenterology and Proctology at the 104th Annual Meeting of the American Medical Association, Atlantic City, June 8, 1955.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?