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A Modified Prothrombin-Consumption Test Using Erythrocytin

ARMAND J. QUICK, M.D.; CLARA V. HUSSEY, M.S.

AMA Arch Intern Med. 1956;97(5):524-531.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The prothrombin-consumption test described by one of us in 1947 ¹ was based on the assumption that the amount of prothrombin remaining in serum when blood clotted under standardized conditions was a measure of the thromboplastin that resulted from the interaction of platelets with a plasma constituent which was designated as thromboplastinogen. It was concluded that the poor consumption of prothrombin observed when hemophilic blood clotted was caused by a lack of this plasma factor and that, therefore, the method could be employed for its assay. This assumption was supported by the significant increase in prothrombin consumption obtained after giving a hemophiliac a transfusion of normal blood or plasma. In mild hemophilia, however, the results were not always consistent, and, peculiarly, it was observed that when the platelet-rich plasma of such patients was clotted the prothrombin consumption was lower and more constant than when the test was done on whole . . . [Full Text PDF of this Article]

Author Affiliations
Milwaukee

From the Department of Biochemistry, Marquette University School of Medicine.

Footnotes
Submitted for publication Oct. 20, 1955.

This work was supported by a grant (H1612 C8) from the National Heart Institute, National Institutes of Health, United States Public Health Center.

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