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Idiopathic Paroxysmal MyoglobinuriaReport of Two Cases and Evaluation of the Syndrome
LEOPOLD REINER, M.D.;
NADYA KONIKOFF, M.D.;
MARK D. ALTSCHULE, M.D.;
GUSTAVE J. DAMMIN, M.D.;
JOHN P. MERRILL, M.D.
AMA Arch Intern Med. 1956;97(5):537-550.
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Idiopathic paroxysmal myoglobinuria is a rare disorder. Adams, Denny-Brown, and Pearson1 in their comprehensive treatise, "Diseases of Muscle," state that they have never seen a case. A search of the literature reveals reports of fewer than two dozén cases, to which we add observations on two others.
REPORT OF CASES
CASE 1.
—A 46-year-old white man of Irish descent was admitted to Beth Israel Hospital in July, 1948, soon after he had suddenly become incapacitated by intolerably painful cramps in his thighs; these had come on without warning when he had attempted to crawl under a fence after climbing a steep hill. He had found himself unable to rise or to straighten himself from the stooped position but had been able to sit with his legs extended. He had perspired profusely during this episode.
Ever since childhood the patient had experienced weakness and pains in the muscles of arms
. . . [Full Text PDF of this Article]
Author Affiliations
New York; Boston
From the Medical Services and Pathology Laboratories, Beth Israel Hospital and Peter Bent Brigham Hospital, and the Departments of Pathology and Medicine, Harvard Medical School. Present address: The Bronx Hospital (57) (Dr. Reiner).
Footnotes
Submitted for publication Oct. 24, 1955.
This work was supported in part by grants from the Medical Research and Development Board, Office of the Surgeon General, Department of the Army, Contract No. DA-49-007-MD-497, and The National Heart Institute, Public Health Service.
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