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A Rational Therapy of Systemic Lupus Erythematosus
N. B. KURNICK, M.D.
AMA Arch Intern Med. 1956;97(5):562-575.
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Our limited knowledge of systemic lupus erythematosus has restricted therapy to empirical and symptomatic approaches. Only corticotropin (ACTH) and the adrenal steroids have been generally accepted as valuable,1 and it is doubtful that these influence the underlying disease.2 Their benefit is probably due to their anti-inflammatory effect. It is the purpose of this paper to report a therapeutic regimen based upon observations 3 on the L. E.-cell phenomenon.4
Klemperer and co-workers 5 have reported that both the L. E.-cell bodies and the hematoxylin bodies found in tissues of patients with lupus contain depolymerized deoxyribonucleic acid (DNA). DNA occurs only in the chromosomes of cell nuclei and is thought to be the principal constituent of the gene, the carrier of hereditary characters. The breakdown of this molecule is probably not compatible with cell survival.
The L. E. cell, thus, represents a nucleolytic phenomenon. The depolymerized nuclear material may
. . . [Full Text PDF of this Article]
Author Affiliations
Long Beach, Calif.
From the Department of Medicine, University of California Medical Center, Los Angeles, and the Veterans Administration Hospital, Long Beach.
Footnotes
Received for publication Oct. 18, 1955.
Presented in part before the Regional Meeting of the American College of Physicians, Coronado, Calif., Feb. 12, 1955.
Aided by grants from the Life Insurance Medical Research Fund, American Cancer Society, and the National Heart Institute, U. S. P. H. S.
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