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Sitosterol Administration in Normal and Hypercholesteremic SubjectsThe Effect in Man of Sitosterol Therapy on Serum Lipids and Lipoproteins
BERNARD A. SACHS, M.D.;
RAYMOND E. WESTON, M.D., Ph.D.
AMA Arch Intern Med. 1956;97(6):738-752.
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The postulated relationship between dietary intake of fats, serum cholesterol level, and the pathogenesis of atherosclerosis has been the basis for the prophylactic use of diets low in fat and cholesterol. The recent demonstration that orally administered plant sterols, without reduction of cholesterol and fat intake, can lower the serum cholesterol levels of animals 1 and man* has provided a new approach to this therapeutic problem. However, failures of treatment with plant sterols to affect serum cholesterol levels of human subjects also have been reported. Because of these discrepant observations, the preliminary results of the present study were withheld until the effects of the more prolonged administration of a mixture of β- and dihydro-β-sitosterols on the serum cholesterol and lipoproteins of normal subjects and hypercholesteremic patients with disorders of lipid metabolism could be evaluated.
MATERIAL AND METHODS
EXPERIMENT A.
—Five normal persons without demonstrable clinical disease and one patient with
. . . [Full Text PDF of this Article]
Author Affiliations
New York
Footnotes
Submitted for publication Nov. 21, 1955. From the Medical Division, Montefiore Hospital.
This study has been supported in part by grants from the Lasdon Foundation; Eli Lilly & Company; National Institute of Arthritis and Metabolic Diseases, U.S.P.H.S.; Medical Research and Development Board, Surgeon General's Office, Department of the Army.
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