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VI. Lactate Metabolism After Infusion of Sodium d-Lactate in Manic-Depressive and Schizophrenic Psychoses

MARK D. ALTSCHULE, M.D.; DOROTHY H. HENNEMAN, M.D.; ROSE-MARIE GONCZ

AMA Arch Intern Med. 1956;98(1):35-38.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Two earlier studies from this laboratory showed that abnormally large amounts of lactic acid accumulate in the blood after administration of glucose ¹ or fructose ² in many patients with schizophrenic or manicdepressive psychoses. Another study³ showed that administration of corticotropin (ACTH) or hydrocortisone to psychotic patients who did not have this abnormality regularly produced it. Other observers had previously demonstrated a disturbance of lactate metabolism during exercise in these psychoses.* In view of these findings, it was decided to study the effects of intravenously infused sodium d-lactate in normal and psychotic subjects.

Materials and Methods

Ten grams of d-lactate, in the form of the sodium salt, was dissolved in 500 ml. of isotonic salt solution and given intravenously in 30 minutes. Blood samples were taken before and at the end of the infusion and again 15 and 30 minutes later. The methods used were as previously . . . [Full Text PDF of this Article]

Author Affiliations
PHYLLIS HOLLIDAY; Waverley, Mass.

From the Laboratory of Clinical Physiology, McLean Hospital, Waverley, and the Department of Medicine, Harvard Medical School, Boston. Mass. Post-Doctoral Fellow, National Institutes of Health (Dr. Henneman).

Footnotes
Submitted for publication Jan. 12, 1956.

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