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III. Results with Mecamylamine, a Completely Absorbed Ganglionic Blocking Agent

JOHN H. MOYER, M.D.; RALPH FORD, M.D.; EDWARD DENNIS, M.D.; COLEMAN CAPLOVITZ, M.D.; ROBERT HERSHBERGER, M.D.; PAUL K. CONNER, M.D.; SAM KINARD, M.D.; ROBERT McCONN, M.D.

AMA Arch Intern Med. 1956;98(2):187-210.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Ganglionic blocking agents appear to be the most potent therapeutic agents for reducing the blood pressure in patients with severe hypertension. However, the orthostatic effect and the variability in blood pressure response to currently available ganglionic blocking agents are the most serious limiting factors in the use of these agents and may completely prohibit their use in some patients. Concurrent administration of rauwolfia, which depresses the sympathetic nervous system in the brain, partially stabilizes the blood pressure response. However, even then extreme variability frequently exists, apparently due to incomplete and variable absorption of these agents (hexamethonium and pentolinium) from the gastrointestinal tract.*

Recently another long-acting gangionic blocking agent has become available for clinical trial. This compound, mecamy- lamine, is a secondary amine (rather than a quaternary compound) which is completely absorbed from the gastrointestinal tract. For this reason it has been investigated as a therapeutic agent for reducing the blood . . . [Full Text PDF of this Article]

Author Affiliations
Houston

From the Departments of Pharmacology and Medicine, Baylor University College of Medicine, and the Cardiac Clinic of the Jefferson Davis Hospital, the Hermann Hospital, and the Medical Service of the Veteran's Administration Hospital.

Footnotes
Submitted for publication Dec. 16, 1955.

Presented by Dr. Moyer at the annual meeting of the American Heart Association, New Orleans, Oct. 24, 1955.

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