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DAVID GROB, M.D.

AMA Arch Intern Med. 1956;98(2):221-239.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE NERVE gases are a group of highly toxic organic esters of phosphoric acid derivatives which have physiologic effects attributable to the inhibition of cholinesterase enzymes. The effects resemble those produced by physostigmine and neostigmine (Prostigmin) but are more intense and more prolonged. The nerve gases are among the most toxic of the chemical warfare agents, and they are the most adaptable to long-range attack, as upon civilian populations.¹ A number of related but somewhat less toxic organic phosphate anticholinesterase compounds have proved to be useful in medicine and in agriculture. Diisoprophyl fluorophosphate (DFP) has been studied in detail* and has been employed as a therapeutic agent in the management of abdominal distention, urinary retention, and glaucoma.⁶ Tetraethylpyrophosphate (TEPP) ⁷ and octamethyl pyrophosphoramide (OMPA) ⁸ proved to be of some value in the management of myasthenia gravis, but they have been replaced by less potent anticholinesterase compounds. Parathion, bis-(monoisopropylamino)-fluorophosphine . . . [Full Text PDF of this Article]

Author Affiliations
Baltimore

From the Department of Medicine, The Johns Hopkins University and Hospital.

Footnotes
Submitted for publication Dec. 12, 1955.

Supported in part by a contract between the U. S. Army Chemical Corps and The Johns Hopkins University.

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