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I. Studies of Plasma 17-Hydroxycorticosteroid Levels

JAYME ROZENBOJM, M.D.; LEWIS J. KRAKAUER, M.D.; SEYMOUR J. GRAY, M.D., Ph.D.

AMA Arch Intern Med. 1956;98(3):266-272.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Adrenal cortical function in gastric cancer has been the subject of previous investigations. Dobriner and co-workers,¹ noting the presence of the abnormal steroid metabolite 11-oxyetiocholanolone on paper chromatography of urinary extracts in gastric cancer patients, postulated a disordered function of the adrenal cortex. This abnormal steroid metabolite was also present in patients with Cushing's disease.²

Young and co-workers,³ studying glucose metabolism in patients with gastric carcinoma, observed that supplementary adrenal cortical extract was necessary to produce normal hepatic glycogen deposition in patients who were receiving oral glucose feedings.

Homburger and co-workers⁴ have reported a disturbed water and electrolyte balance in gastric cancer patients, simulating in some respects that seen in adrenal hypofunction.

Rhoads⁵ applied the Kepler and the Cutler-Power-Wilder tests to two patients with gastric cancer in order to investigate the connection, if any, between neoplasm of the stomach and adrenal hormonal imbalance. The results . . . [Full Text PDF of this Article]

Author Affiliations
Boston

From the Medical Clinic, Peter Bent Brigham Hospital and the Department of Medicine, Harvard Medical School.

Footnotes
Submitted for publication April 5, 1956.

This work was supported in part by the United States Public Health Service and the Gastrointestinal Fund of the Peter Bent Brigham Hospital.

Fellow of the W. K. Kellogg Foundation and the American College of Physicians (Dr. Rozenbojm); This work was done during the tenure of a Postdoctorate Research Fellowship from the National Cancer Institute (Dr. Krakauer); Assistant Professor of Medicine, Harvard Medical School (Dr. Gray).

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