This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (102)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Information Obtained with Radioactive Vitamin B12

PATRICIA A. McINTYRE, M.D.; MARIE V. SACHS, A.B.; JULIUS R. KREVANS, M.D.; C. LOCKARD CONLEY, M.D.

AMA Arch Intern Med. 1956;98(5):541-549.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The clinical manifestations of pernicious anemia are believed to be wholly attributable to a deficiency of vitamin B₁₂. This deficiency is not the result of improper diet but is caused by impaired absorption of the vitamin from the gastrointestinal tract. For vitamin B₁₂ to be absorbed in adequate amounts, a substance present in the secretion of the normal stomach is required. This substance, the intrinsic factor of Castle, has not yet been identified or obtained in pure form. The mode of action of intrinsic factor is unknown, but virtually all evidence indicates that it simply facilitates the absorption of vitamin B₁₂. The basic defect in pernicious anemia is an abnormality of the stomach which fails to produce intrinsic factor. As a result vitamin B₁₂ is not absorbed even though ingested in usual amounts. Similar deficiency states are encountered with certain other disorders of the alimentary canal in which there is . . . [Full Text PDF of this Article]

Author Affiliations
Baltimore

From the Department of Medicine, The Johns Hopkins University and Hospital.

Footnotes
Submitted for publication June 1, 1956.

Clinical Fellow of the American Cancer Society (Dr. McIntyre).

This work was carried out under Contract AT (30-1) 1208 between the Atomic Energy Commission and The Johns Hopkins University. The vitamin B12 used in these studies was generously provided by Merck & Co., Inc. The intrinsic factor concentrate was kindly supplied by Organon, Inc.

Read in the Symposium on Hematology of the Joint meeting of the Section on Experimental Medicine and Therapeutics and the Section on Internal Medicine at the 105th Annual Meeting of the American Medical Association, Chicago, June 14, 1956.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?