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mechanisms of Destruction of Red Cells in Certain Hemolytic Conditions
THOMAS HALE HAM, M.D.;
RUSSELL WEISMAN, Jr., M.D.;
CARL F. HINZ, Jr., M.D.
AMA Arch Intern Med. 1956;98(5):574-592.
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Understanding of the natural history of the anemias associated with increased destruction of red cells has been advanced in the past 20 years, as indicated in recent reviews.* In this report the characteristics of the red cell and the sites and mechanisms of hemolysis are considered for normal red cells and for certain hereditary, congenital, and acquired hemolytic conditions. An attempt is made to indicate the significance and limitations of knowledge concerning the hemolytic processes. More complete details concerning the pathologic physiology and, especially, the clinical aspects of hemolytic conditions are found elsewhere.f The normal red cell is a biconcave disc containing from 32 to 34 gm. of hemoglobin per 100 ml. of packed red cells. The mechanism which holds the red cell in its unique
I. Normal Red Blood Cells and Effect of Incubation
Characteristics of the Normal Red Cell Compared to Certain Abnormal Forms
shape has not been
. . . [Full Text PDF of this Article]
Footnotes
Submitted for publication June 15, 1956.
From Western Reserve University School of Medicine and the University Hospitals, Cleveland. This investigation was supported in part by a grant from the United States Public Health Service (Grant No. H-1263).
Read in the Symposium on Hematology of the Joint Meeting of the Section on Experimental Medicine and Therapeutics and the Section on Internal Medicine at the 105th Annual Meeting of the American Medical Association, Chicago, June 14, 1956.
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