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M. B. LIPSETT, M.D.; M. C. LI, M.D.; O. H. PEARSON, M.D.

AMA Arch Intern Med. 1956;98(5):634-638.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Bilateral adrenalectomy or hypophysectomy will induce objective remissions in some patients with metastatic breast cancer. It is the purpose of this report to detail our methods for managing patients subjected to these procedures. These methods are based on clinical experience and physiological studies of over 200 patients submitted to either adrenalectomy or hypophysectomy. We shall attempt to describe the general medical management for both procedures and to suggest specific methods for handling the problems peculiar to patients with metastatic disease.

Huggins and Scott,¹ in 1945, reported the initial experiences with bilateral adrenalectomy in four patients with advanced prostatic cancer. With the use of desoxycorticosterone and adrenal cortical extract they were unable to maintain life in their patients, although one patient survived almost four months. Subsequently, Green and co-workers² successfully managed adrenalectomy in a diabetic patient with the use of large amounts of adrenal cortical extracts. With the availability . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Division of Clinical Investigation, Sloan-Kettering Institute for Cancer Research; Medical Service, Memorial Center; and Sloan-Kettering Division, Cornell University Medical College.

Footnotes
Submitted for publication April 5, 1956.

Dr. B. S. Ray, Dr. C. D. West, and Dr. J. P. Maclean collaborated and assisted in this work.

These studies were supported in part by grants from the National Cancer Institute, National Institutes of Health, United States Public Health Service, C-925 (C6), C-2126; the United States Atomic Energy Commission; the American Cancer Society, Inc., and the Damon Runyon Memorial Fund.

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