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ALVIN L. SELLERS, M.D.

AMA Arch Intern Med. 1956;98(6):801-806.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The supposition that the glomerular filtrate is protein-free is based on the classical experimental studies of Wearn and Richards.¹ They found glomerular fluid, obtained by micropuncture from Bowman's capsule, to be "protein free" or at least to contain less than 30 mg. per 100 ml. of protein, which was the least amount that could be detected by the methods at their disposal. As Addis² has pointed out, this supposition might be readily accepted were it not that the volume of glomerular filtrate in man is approximately 180,000 ml. per 24 hours, so that even if the protein concentration was as little as 10 mg. per 100 ml., 18,000 mg. would pass through the membrane daily. Considerations of this sort stimulated workers in the field, so that during the past 10 years our knowledge of the passage of proteins through the kidney has advanced to the point where a . . . [Full Text PDF of this Article]

Author Affiliations
Los Angeles

Footnotes
Received for publication June 25, 1956.

Institute for Medical Research, Cedars of Lebanon Hospital, and the Department of Medicine, University of Southern California, School of Medicine.

Read before the Section on Experimental Medicine and Therapeutics at the 105th Annual Meeting of the American Medical Association, Chicago, Tune 13, 1956.

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