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Observations on the Effects of Probenecid and Acetazoleamide in Two Patients

ROBERT B. BAER, M.D.; THOMAS BENEDEK, M.D.; IRAM. ROSENTHAL; HYMAN J. ZIMMERMAN, M.D.

AMA Arch Intern Med. 1957;99(1):14-21.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Pseudohypoparathyroidism, a disease first described by Albright and co-workers,¹ differs from true hypoparathyroidism in pathogenesis despite the biochemical and clinical similarities of the two conditions.^1-6 High serum phosphorus levels and low serum calcium levels are characteristic of both conditions. Hypocalcemic tetany, intracranial calcification, and cataracts may be found in both diseases (Table). While true hypoparathyroidism results from a deficiency in circulating parathyroid hormone, pseudohypoparathyroidism seems to be the result of inadequate end-organ response to parathyroid secretion.¹ Differences in response to injected parathyroid extract have been used for the differential diagnosis of the two diseases.^1,2 Despite the underlying difference in pathophysiology, the treatment of pseudohypoparathyroidism, like that of true hypoparathyroidism, has been based on the administration of either dihydrotachysterol or vitamin D and a low-phosphorus diet.^1-3 In general, the response of patients with true hypoparathyroidism has been more satisfactory.³

Probenecid (Benemid) has been reported to have an effect on phosphorus metabolism . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

Medical Service, West Side Veterans Administration Hospital, and Departments of Medicine and Pediatrics, University of Illinois College of Medicine. Formerly Resident in Medicine, West Side Veterans Administration Hospital (Dr. Baer); formerly Resident in Medicine, Research and Educational Hospitals, University of Illinois (Dr. Benedek); Associate Professor of Pediatrics, University of Illinois College of Medicine (Dr. Rosenthal), and Chief Medical Service, West Side Veterans Administration Hospital, and Clinical Associate Professor of Medicine, University of Illinois College of Medicine (Dr. Zimmerman).

Footnotes
Submitted for publication May 16, 1956.

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