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VII. The Effect of Glutathione on Carbohydrate Intermediary Metabolism in Schizophrenic and Manic-Depressive Psychoses

MARK D. ALTSCHULE, M.D.; DOROTHY H. HENNEMAN, M.D.; PHYLLIS D. HOLLIDAY; ROSE-MARIE GONCZ

AMA Arch Intern Med. 1957;99(1):22-27.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Patients with schizophrenic, manic-depressive, and involutional psychoses have a disorder of carbohydrate metabolism; the origin of this disorder is as yet unknown.¹ However, it is known that it is not due to hepatic dysfunction,² that it is not remedied by thiamine, and that it disappears only with remission of the psychoses, regardless of how remission has come about. It also is known that patients with these psychoses commonly have blood glutathione levels that are in or below the lower range of normal.³ Glutathione is an important coenzyme in several metabolic processes, and it also may have other functions in intermediary metabolism; at any rate, observations in man⁴ indicate that it accelerates carbohydrate utilization. In view of these facts, it was decided to study the effects of the administration of glutathione on the carbohydrate metabolism of patients with the above-mentioned psychoses.

Material and Methods

Five patients were . . . [Full Text PDF of this Article]

Author Affiliations
Waverley, Mass.; Boston; Waverley, Mass.

From the Laboratory of Clinical Physiology, McLean Hospital, Waverley, Mass., and the Department of Medicine, Harvard Medical School, Boston.

Footnotes
Submitted for publication May 17, 1956.

This study was aided by a grant from the Commonwealth Fund and by a donation from Arnold S. and Marjorie F. Dane, of Marblehead, Mass.; some of the glutathione used was made available without cost by the Schwarz Laboratories, Inc., Mount Vernon, N. Y.

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