This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

RICHARD S. YOCUM, M.D.; ALEXANDER A. DOERNER, M.D.

AMA Arch Intern Med. 1957;99(1):74-81.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

In response to a variety of inflammatory lesions, there appears in the blood of humans a protein substance not normally present, which is identified by its capacity to form a precipitate with the somatic Cpolysaccharide of the pneumococcus.¹ It has consequently been named C-reactive protein (CRP). Present knowledge points toward C-reactive protein being a β-globulin, probably bound to a lipid. Minute amounts of this protein may be demonstrated in human serum by a precipitin test employing a specific antiserum obtained from rabbits hyperimmunized by repeated injections of a purified C-reaction protein. In previous studies it has been demonstrated that the appearance of C-reactive protein in the blood is a nonspecific but extremely sensitive indicator of an inflammatory reaction due to infection. It has also been found in other disease processes of a noninfectious nature, such as malignancy and myocardial infarction. Kroop and Shackman ² reported negative tests in . . . [Full Text PDF of this Article]

Author Affiliations
Washington, D. C.; San Francisco

From the U. S. Public Health Service Hospital, San Francisco; Senior Resident (Dr. Yocum) and Chief (Dr. Doerner), Medical Service. Present address of Dr. Yocum: U.S. Public Health Service Outpatient Clinic, 4th & D Sts., S.W. (25).

Footnotes
Submitted for publication April 26, 1956.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?