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JACOB GROSSMAN, M.D.

AMA Arch Intern Med. 1957;99(1):93-128.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Notwithstanding the fact that much of modern physiology has concerned itself with the maintenance of constancy of the milieu intérieur, a definite lag persisted in the study and understanding of those factors regulating the normal volume and distribution of body fluids. Starling, with his rare insight, had early called attention to the fact that such control must exist,²⁰⁰ and experiments supporting this idea were subsequently reported,^1,8 but the implications of the results—far ahead of the conceptual thinking of the time—fell upon soil unprepared for germination.

Historically, several factors contributed to the delayed growth of knowledge of fluid volume regulation. Measurements of body fluid constituents by the standard chemical methods are reported, in the language of chemists, as concentrations, and so accustomed have we become to this method of expression that students frequently find it difficult to associate a normal concentration with a highly abnormal amount of substance in . . . [Full Text PDF of this Article]

Author Affiliations
New York

Footnotes
Submitted for publication May 31, 1956.

Medical Division, Montefiore Hospital. Work of this laboratory is supported in part by grants from the National Heart Institute, U. S. P. H. S., Eli Lilly & Company, Wyeth Laboratories, Inc., G. D. Searle & Co., Sandoz Pharmaceuticals, the New York Heart Association, and the American Heart Association.

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