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Report of Twenty-Three Cases with a Note on Hepatic Involvement in Mumps

ROBERT G. PETERSDORF, M.D.; IVAN L. BENNETT, Jr., M.D.

AMA Arch Intern Med. 1957;99(2):222-233.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Epididymo-orchitis occurs as a complication in the course of mumps in 18% to 43% of postpubertal males.^1-4 Not only is gonadal involvement accompanied by severe local pain and systemic discomfort, but testicular atrophy is a sequel in about one-half of the cases, and sterility can result, although this is probably unusual.^5,6 Of the various prophylactic measures that have been tried in males with epidemic parotitis, the administration of diethylstilbestrol has given encouraging results,^7,8 and early injection of -globulin prepared from mumps convalescent serum has resulted in definite reduction in the incidence of orchitis.⁹ The treatment of established orchitis, however, has remained unsatisfactory. Antibiotics,^10-14 pooled plasma,^15-17 convalescent serum,¹⁸ estrogens,⁷ and surgical decompression ^19-21 have been irregularly effective. At present, the usual regimen consists of analgesic and antipyretic drugs with local application of cold and the use of various suspensory devices.

The few available descriptions of the histologie characteristics of mumps orchitis²⁰ . . . [Full Text PDF of this Article]

Author Affiliations
Baltimore

Footnotes
Submitted for publication May 15, 1956.

From the Biological Division of the Department of Medicine, The Johns Hopkins University School of Medicine. Aided by Grant A-660 of the National Institute of Arthritis and Metabolic Diseases, U. S. Public Health Service. Research Fellow of the National Foundation for Infantile Paralysis (Dr. Petersdorf); Associate Professor of Medicine, The Johns Hopkins University (Dr. Bennett).

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