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An Aid to the Differential Diagnosis of Nontoxic Disease of the Thyroid

PENN G. SKILLERN, M.D.; BURTIS R. EVANS, M.D.

AMA Arch Intern Med. 1957;99(2):234-244.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The thyroidal radioactive iodine (I¹³¹) uptake alone has only been of limited value as a diagnostic aid in the differential diagnosis of nontoxic thyroid disease. However, measurement of the thyroidal uptake of radioactive iodine (I¹³¹)* before and after the administration of thyroid-stimulating hormone (thyrotropin) has greatly enhanced the usefulness of this diagnostic tool. The purpose of this paper is to describe the results of the thyroid-stimulating hormone (TSH) test in patients having various nontoxic thyroid diseases with and without goiter and patients with normal thyroid function.

Review of the Literature

Stanley and Astwood ¹ first demonstrated that in patients with normal thyroid function (euthyroidism) a single injection of TSH caused a significant increase in the rate of thyroidal uptake of I¹³¹ at the end of 8 hours which reached its peak at the end of 24 hours. They noted that the duration of the increased rate of . . . [Full Text PDF of this Article]

Author Affiliations
Cleveland

From the Department of Endocrinology, The Cleveland Clinic Foundation, and The Frank E. Bunts Educational Institute. Former Fellow in Division of Medicine, Cleveland Clinic (Dr. Evans).

Footnotes
Submitted for publication June 20, 1956.

Present address of Dr. Evans: 508 E. S. Temple, Salt Lake City.

Read before the Section on Internal Medicine at the 105th Annual Meeting of the American Medical Association, Chicago, June 12, 1956.

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