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Idiopathic Paroxysmal MyoglobinuriaDetailed Study of a Case Including Radioisotope and Serum Enzyme Evaluations
CARL M. PEARSON, M.D.;
WILLIAM S. BECK, M.D.;
WILLIAM H. BLAHD, M.D.
AMA Arch Intern Med. 1957;99(3):376-389.
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The liberation of myoglobin pigment from striated muscle and its subsequent appearance in the urine is a dramatic, potentially serious, and fortunately rather rare occurrence. Many types of traumatizing damage to muscle fibers may cause a partial or complete dissolution of the muscle sarcoplasm with the release of myoglobin and probably many other of the intracellular components. Some of these substances enter the circulation, and myoglobin, at least, is excreted by the kidney. Hence, myoglobinuria is not associated specifically with any single disease process but is a sign of severe damage to a significant mass of striated muscle.
In addition to the traumatic myopathies, there have been reported a number of cases of myoglobinuria, usually recurrent and unassociated with any traumatic or toxic event. About one-third of these have been associated with muscular dystrophy. The remainder of the cases, 20 in number, have been idiopathic and unassociated with any specific
. . . [Full Text PDF of this Article]
Author Affiliations
Los Angeles
From the Division of Neurology, Department of Medicine, University of California Medical Center, Los Angeles 24, and Wadsworth Hospital Veterans Administration Center, Los Angeles 25.
Footnotes
Submitted for publication Aug. 17, 1956.
Supported in part by a grant-in-aid from the Muscular Dystrophy Associations of America, Inc.
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