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JAMES E. KELSEY, M.D.; E. C. OLDHAM, B.S.; STEVEN M. HORVATH, Ph.D.

AMA Arch Intern Med. 1957;99(3):411-417.

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Chronic pulmonary disease, particularly emphysema, presents a problem in a hospital treating males of the older age group. Pulmonary emphysema may be encountered as a complication of any disease, but in spite of its high incidence, little is known concerning its basic abnormal physiology. The importance of carbon dioxide in the control of respiration was first considered by Miescher-Rush, cited by Best and Taylor,¹ in 1885, and amplified by Haldane and Priestley,² who pointed out the importance of the blood pCO₂ as one of the controlling factors. Scott³ related the ventilatory response of his subjects to the inhalation of CO₂ in varying concentrations in view of the emphysematous patient's increased tolerance to a high alveolar CO₂ concentration. He concluded that the diminished response in the emphysematous persons as compared with the normal was due to the increased buffering capacity of the body fluids. Donald and Christie⁴ expanded Scott's work . . . [Full Text PDF of this Article]

Author Affiliations
Des Moines, Iowa; lowa City

From the Department of Internal Medicine and the Laboratory Service, Veterans Administration Hospital, Des Moines, Iowa; Department of Internal Medicine (Dr. Kelsey); Biochemist, Laboratory Service (Mr. Oldham). Professor, Department of Physiology, State University of Iowa College of Medicine, Iowa City (Dr. Horvath).

Footnotes
Submitted for publication June 12, 1956.

Sponsored by the Veterans Administration with the approval of the Chief Medical Director.

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