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Studies on the Relationship Between the Peripheral Blood Counts and the Total Body Red Cell VolumeII. In Patients with Addisonian Pernicious Anemia in Relapse, During Recovery, and in Remission
S. FRED RABINER, M.D.;
HERBERT C. LICHTMAN, M.D.
AMA Arch Intern Med. 1957;99(3):474-480.
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Introduction
It has been shown previously that in normal persons there is a relatively constant relationship between the hematocrit of peripheral venous blood and the circulating red blood cell volume per kilogram of body weight (CRBCV/kg.). In these instances the hematocrit is a useful and practical indicator of the size of the erythron. However, in patients with polycythemia vera and in certain persons in whom the peripheral hematocrit is abnormally high, this relationship was found to be unreliable.1 The ratio, hematocrit of peripheral venous blood divided by CRBCV/kg.  , gives an indication of the relative error of the hematocrit which may be spuriously normal, elevated, or low.
In the present study this relationship was determined in patients with Addisonian pernicious anemia in relapse, during regeneration in response to specific therapy, and in remission. It was found in patients who were in hematologic relapse that the venous hematocrit correlated poorly
. . . [Full Text PDF of this Article]
Author Affiliations
Brooklyn
From the Department of Medicine, The State University of New York, College of Medicine at New York City; Assistant Instructor (Dr. Rabiner) and Associate Professor (Dr. Lichtman).
Footnotes
Submitted for publication June 20, 1956.
Miss Rosalie Lesser and Miss Mildred Fishman gave technical assistance.
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