 |
|
Recent Studies Relative to the Treatment of DiabetesSpecial Reference to New Oral Antidiabetic Drugs
ROBERT H. WILLIAMS, M.D.;
ELAINE D. HENLEY, M.D.
AMA Arch Intern Med. 1957;99(4):501-518.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
|
|
|
Pathogenesis of Diabetes
Elucidation of the pathogenesis of a disease prompts a rational search for the most appropriate therapy. In the majority of patients with diabetes mellitus, the pathogenesis has not been established, but significant contributory factors have been demonstrated in some instances.
Decreased Insulin Secretion.
—A marked decrease in pancreatic islet tissue, whether produced by carcinomatosis, pancreatitis, extirpation, or in other ways, has been found to cause diabetes. But in the majority of patients, apparently there is insufficient morphologic abnormality to account for the development of this disorder. It could be postulated that a biochemical defect in the β-cells is associated with a decreased insulin synthesis and/or release. Such a concept deserves notation in considering the possible mechanisms of action of sulfonylureas, discussed later.
Relative Insufficiency of Insulin Secretion.
—There are many conditions that are associated with the development of diabetes in which there is reason for assuming that
. . . [Full Text PDF of this Article]
Author Affiliations
Seattle
From the Department of Medicine, University of Washington School of Medicine.
Footnotes
Submitted for publication Dec. 18, 1956.
Presented in part before the American Chemical Society, Sept. 18, 1956, and the American Medical Association, Nov. 30, 1956.
Aided by grants from the Atomic Energy Commission, the United States Public Health Service, and the Diabetes Teaching and Research Foundation.
Special article.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
|
