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Pneumococcal Endocarditis, Meningitis, and Rupture of the Aortic Valve
ROBERT AUSTRIAN, M.D.
AMA Arch Intern Med. 1957;99(4):539-544.
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The advent of an effective prophylactic and therapeutic agent may alter significantly both the incidence and etiology of a given anatomical lesion, and such may be the effect of penicillin upon aortic valvular disease. As a result of its use in the treatment of early syphilis, syphilitic disease of the aortic valve is seen with lessening frequency, and it is altogether possible that the widespread employment of penicillin as a prophylactic against rheumatic fever may result in a decrease in aortic valvular disease of rheumatic origin. Concomitant with the decline of two of the major causes of aortic valvular disease, lesions of other etiologies will acquire relatively greater significance, and, paradoxically, antibiotics and notably penicillin can be responsible for the emergence of one of these. By preventing the premature death of patients with pneumococcal endocarditis, a hitherto almost uniformly fatal disorder, penicillin enables some of these persons to recover from
. . . [Full Text PDF of this Article]
Author Affiliations
Brooklyn
From the Department of Medicine, State University of New York College of Medicine at New York City.
Footnotes
Submitted for publication Dec. 19, 1956.
This paper was presented at the Sixty-Ninth Annual Meeting of the American Clinical and Climatological Association, Nov. 1, 1956, and will be published in the Transactions of the Association.
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