This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal

MURRAY CHINSKY, M.D.; SOL SHERRY, M.D.

AMA Arch Intern Med. 1957;99(4):556-568.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Glutamic oxaloacetic transaminase, an enzyme which catalyzes the reversible transamination reaction by which glutamate and oxaloacetate interact to form aspartate and -ketoglutarate, is present in high concentration in a number of animal tissues, but most notably in heart, liver, kidney, muscle, and brain.¹

The serum or plasma level of glutamic oxaloacetic transaminase, henceforth referred to as transaminase in this report, has recently come into prominence as a diagnostic aid in clinical medicine.^2-11 Following the initial observations by Karmen, Wróblewski and LaDue that all normal human sera contain transaminase activity and the development by Karmen of a simple technique for the quantitative assay of serum transaminase,³ LaDue and his associates demonstrated that acute cardiac, hepatic, and skeletal muscle necrosis in man was associated with a significant rise in the level of serum transaminase activity.^2,4,5 These initial observations have been confirmed both in man ^7-11 and under experimental conditions . . . [Full Text PDF of this Article]

Author Affiliations
St. Louis

Footnotes
Submitted for publication June 27, 1956.

From the Medical Section, the Research Institute of the Jewish Hospital of St. Louis, and the Department of Medicine, Washington University School of Medicine. This work was supported by a grant-in-aid from the St. Louis Heart Association.