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FRED S. GRODINS, M.D.

AMA Arch Intern Med. 1957;99(4):569-572.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To understand the nature of disturbances in acid-base balance and the role of respiration in their initiation or compensation, it is necessary first to inquire into the operation of the blood buffer systems. The total "base" cations of the blood, B_t (chiefly Na+ and K+), are distributed among "acid" anions as follows:

where P is protein, A is chiefly chloride, and X includes such things as phosphate, sulfate, and lactate. Now in a given blood subject to changes only in carbonic acid (or pCO₂), BA is constant and BX is negligibly small. We therefore concentrate our attention on that part of B_t which is distributed between HCO₃— and P—. Let us call this the "buffer base," B_b, and define it as follows:

When carbonic acid is added to such blood, the total buffer base remains constant, but its distribution between HCO₃— and . . . [Full Text PDF of this Article]

Author Affiliations
Chicago

Footnotes
Submitted for publication June 24, 1956.

Read before the Section on Pathology and Physiology at the 105th Annual Meeting of the American Medical Association, Chicago, June 12, 1956.

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