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The Treatment of Ulcerative Colitis
JOSEPH B. KIRSNER, M.D., Ph.D.;
RICHARD O. BICKS, M.D.;
WALTER L. PALMER, M.D., Ph.D.
AMA Arch Intern Med. 1957;99(4):642-655.
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Introduction
Ulcerative colitis is an acute and chronic disease of the colon and rectum, characterized clinically by bloody diarrhea, cramping abdominal pain, malaise, anorexia, fever, and weight loss.1,2 Proctoscopic examination of the rectum and sigmoid reveals, in approximately 95% of cases, diffuse inflammation, with edema, granularity, ulceration, and friability of the mucosa and sanguinopurulent exudation. Roentgen study demonstrates loss of normal haustration of the colon, decreased distensibility, narrowing and ulceration of the bowel, and pseudopolypoid changes in the mucosa. The entire colon and rectum appear involved roentgenologically in approximately 50% of cases; in perhaps 10% the x-ray appearance is normal, presumably owing to limitation of the process to the mucosa; in the remaining 40% varying portions of the bowel are diseased. The adjacent terminal ileum also is affected in 10% to 15% of patients.3 Ileocolitis involves chiefly the distal portion of the ileum, the cecum, and the ascending
. . . [Full Text PDF of this Article]
Author Affiliations
Chicago
Department of Medicine, University of Chicago. Clinical Trainee, National Institute of Arthritis and Metabolic Diseases, U. S. Public Health Service (Dr. Bicks).
Footnotes
Submitted for publication Dec. 10, 1956.
These studies are supported in part by the Wallach Fund for Research in Gastrointestinal Diseases, University of Chicago.
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