This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (13)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

ROY C. GUMPEL, M.D.; EDWARD C. LEWIS, M.D.; ROBERT V. THOMSON, M.D.

AMA Arch Intern Med. 1957;99(4):660-668.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Corticotropic hormones and adrenal corticosteroids have proven to be the sine qua non of replacement therapy in certain pituitary and adrenal gland disorders. Although not a therapeutic panacea, the value of the induced hyperadrenal state in many additional illnesses has been established. Unfortunately, the occurrence of occasional deleterious side-reactions and untoward symptoms of overdosage have established their action to be as that of a "two-edged sword."

Among the complications of corticotropin and adrenal cortical hormone therapy, none are associated with a graver morbidity or higher mortality than are those involving the gastrointestinal system. The appearance of ulcerations of the duodenum and stomach with a high incidence of perforation and hemorrhage has been recognized with increased frequency and has led to a curtailment in the use of hormone therapy and to the use of a prophylactic ulcer regimen in cases where such therapy is mandatory. The hormones have resulted in the . . . [Full Text PDF of this Article]

Author Affiliations
Coral Gables, Fla.

Footnotes
Recorded for publication Aug. 22, 1956.

Resident, Medical Service (Dr. Gumpel); Resident, Surgical Service, (Dr. Lewis), and Pathologist (Dr. Thomson), Veterans Administration Hospital.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?