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KURT LANGE, M.D.; RUTH STRANG, M.D.; LAWRENCE B. SLOBODY, M.D.; EUGENE J. WENK, M.A.

AMA Arch Intern Med. 1957;99(5):760-770.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The "nephrotic syndrome" may be defined as a combination of clinical and laboratory findings including massive edema, marked proteinuria, hypoproteinemia, and hyperlipemia. This syndrome may be associated with such diseases as diabetes mellitus (Kimmelstiel-Wilson syndrome), renal amyloidosis, renal vein thrombosis, syphilis, and heavy-metal poisoning. However, in common usage nephrosis or the nephrotic syndrome refers to the so called "pure" or "lipid" nephrosis and to the nephrotic stage of glomerulonephritis. It is possible that the latter two forms are caused by the same basic mechanisms.

Pathogenesis and Pathologic Physiology

We believe that nephrosis is a distinct disease with an immunologic basis and is characterized by a complement-binding antigen-antibody reaction. This antigen-antibody reaction acts to produce functional and, when persistent, morphologic tissue damage. It is probable that not only the glomerular capillary but many of the other capillaries in the body are similarly altered, leading to a generalized increase in glomerular and . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Departments of Medicine and Pediatrics, New York Medical College-Metropolitan Medical Center.

Footnotes
Submitted for publication July 23, 1956.

Presented in part as a Scientific Exhibit at the Annual Meeting of the American Medical Association, 1955.

Aided by grant 302(R) of the National Institute of Arthritis and Metabolic Diseases of the National Institutes of Health, Public Health Service, Bethesda, Md. and a grant of the Nephrosis Foundation of New York and New Jersey.

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