This Article  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A New Approach to Its Management

HAROLD B. EIBER, M.D.

AMA Arch Intern Med. 1957;99(5):833-839.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

This exhibit presents a graphic report on two studies, both of which were designed to evaluate chlorpromazine hydrochloride and Rauwolfia serpentina used in combination. The first study is an extensive investigation of the combination in the treatment of 350 hypertensive patients; the second, a preliminary trial of the combination in 50 neuropsychiatric patients.

Hypertensive Study

Unfortunately there is no safe, effective single drug for the treatment of moderate and severe hypertension. The potent drugs commonly used in these conditions (hexamethonium, pentolinium, the veratrums, hydralazine, et al.) are fairly unpredictable in action, and because the margin between their effective and toxic dose is small, the side-effects which they cause are numerous, annoying, and not infrequently dangerous.

Rauwolfia serpentina, an agent capable of producing a slow, gradual lowering of blood pressure, has been found valuable in treating mild hypertension. Chlorpromazine, which often exerts an immediate, slight hypotensive affect as a hypotensive agent, . . . [Full Text PDF of this Article]

Author Affiliations
New York

New York Medical College, Metropolitan Medical Center.

Footnotes
Submitted for publication Dec. 9, 1956.

Shown as a Scientific Exhibit of the Section on Experimental Medicine and Therapeutics at the 104th Annual Meeting of the American Medical Association, Atlantic City, N. J., June 6-10, 1955.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?