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CECIL K. DRINKER, M.D.; SAMUEL H. HURWITZ, M.D.

Arch Intern Med. 1915;XV(5 1):733-745.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Within the past two years it has become more and more possible to study the factors concerned in blood coagulation. The literature of this period has even given promise of an etiological classification of hemorrhagic disease, but developments have not borne out this promise. If we accept the theory of Howell,¹ there are five factors in coagulation — antithrombin, thromboplastin, calcium salts, prothrombin and fibrinogen — which may show variations in disease. Antithrombin, prothrombin, calcium salts and fibrinogen are present in the circulating blood. The prothrombin, however, is held in combination with antithrombin and thus prevented from activation into thrombin by calcium. Without thrombin there can be no coagulation. The presence of thrombin is secured through the fixation or neutralization of antithrombin by thromboplastin. This last substance, thromboplastin, frees the blood of antithrombin; under these conditions calcium at once forms thrombin from prothrombin; thrombin reacts with . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Peter Bent Brigham Hospital, Boston.

Footnotes
Submitted for publication Nov. 20, 1914.

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